Structured Summary
Abstract
Complex cytotoxic antibiotic obtained from Streptomyces flocculus or S. rufochronmogenus. It is used in advanced carcinoma and causes leukopenia.
Chemical Identity
Chemical Information
- Molecular Formula
- C25H22N4O8
- Molecular Weight
- 506.5 g/mol
- CAS Registry No.
- 3930-19-6
- IUPAC Name
- 5-amino-6-(7-amino-6-methoxy-5,8-dioxoquinolin-2-yl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpyridine-2-carboxylic acid
- InChIKey
- PVYJZLYGTZKPJE-UHFFFAOYSA-N
- SMILES
- CC1=C(C(=C(N=C1C(=O)O)C2=NC3=C(C=C2)C(=O)C(=C(C3=O)N)OC)N)C4=C(C(=C(C=C4)OC)OC)O
- MeSH Unique ID
- D013308
- Source
- PubChem CID 5298
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
7 entry terms
- Brunemycin
- Bruneomycin
- Rufocromomycin
- NSC-45383
- Nigrin
- NSC 45383
- NSC45383
MeSH Record
Aspects Covered
26 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
73(65)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Streptonigrin. Medical Subject Headings (MeSH). 2026. Unique ID D013308. http://id.nlm.nih.gov/mesh/2026/D013308
- Streptonigrin. In: Wikipedia. https://en.wikipedia.org/wiki/Streptonigrin
- Streptonigrin. In: Wikidata. https://www.wikidata.org/wiki/Q15427845
- Streptonigrin. In: PubChem Compound. CID 5298. https://pubchem.ncbi.nlm.nih.gov/compound/5298