Chemicals and Drugs

Subfamily A ATP Binding Cassette Transporter

A large, highly conserved, subfamily of ATP binding cassette transporters structurally characterized by a membrane-spanning domain composed of six ALPHA-HELICES, a large extracellular loop, nucleotide-binding domain, and a conserved cytoplasmic 80 amino acid sequence. In humans, it includes ABCA1(ATP BINDING CASSETTE TRANSPORTER 1) through ABCA10, as well as ABCA12 and ABCA13.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A large, highly conserved, subfamily of ATP binding cassette transporters structurally characterized by a membrane-spanning domain composed of six ALPHA-HELICES, a large extracellular loop, nucleotide-binding domain, and a conserved cytoplasmic 80 amino acid sequence. In humans, it includes ABCA1(ATP BINDING CASSETTE TRANSPORTER 1) through ABCA10, as well as ABCA12 and ABCA13.

MeSH Record

Classification

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MeSH Record

Synonyms

5 entry terms
  • ABCA Transporters
  • ATP Binding Cassette Transporter, Sub-Family A
  • ATP Binding Cassette Transporter, Subfamily A
  • ATP Binding Cassette Transporter, Sub Family A
  • Transporters, ABCA

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2019 (2018)

MeSH Record

Previous Indexing

  • ATP-Binding Cassette Transporters (2001-2017)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.430w.890w.020w.381
  2. D12.776w.157w.530w.100w.050
  3. D12.776w.395w.550w.020w.381
  4. D12.776w.543w.550w.192w.381
  5. D12.776w.543w.585w.100w.190

AMA Style

References

  1. National Library of Medicine. Subfamily A ATP Binding Cassette Transporter. Medical Subject Headings (MeSH). 2026. Unique ID D000073874. http://id.nlm.nih.gov/mesh/2026/D000073874
  2. Subfamily A ATP Binding Cassette Transporter. In: Wikidata. https://www.wikidata.org/wiki/Q24727822