Chemicals and Drugs

Sulbactam

A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.

Chemical Identity

Chemical Information

Molecular Formula
C8H11NO5S
Molecular Weight
233.24 g/mol
CAS Registry No.
68373-14-8
IUPAC Name
(2S,5R)-3,3-dimethyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
InChIKey
FKENQMMABCRJMK-RITPCOANSA-N
SMILES
CC1([C@@H](N2[C@H](S1(=O)=O)CC2=O)C(=O)O)C
MeSH Unique ID
D013407
Source
PubChem CID 130313

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

9 entry terms
  • Penicillanic Acid Sulfone
  • Sulfone, Penicillanic Acid
  • Bétamaze
  • CP-45899
  • Combactam
  • Sulbactam Sodium
  • CP 45899
  • CP45899
  • Sodium, Sulbactam

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

88

MeSH Record

Previous Indexing

  • Beta Lactamases/antagonists & inhibitors (1979-1987)
  • Enzyme Inhibitors (1975-1987)
  • Enzymes/antagonists & inhibitors (1966-1974)
  • Penicillanic Acids (1971-1987)

MeSH Hierarchy

Tree Numbers

  1. D02w.065w.589w.099w.750w.812w
  2. D02w.886w.108w.750w.812w
  3. D03w.633.100.300w.750w.812w

MeSH Record

NLM Classification

QV 354

AMA Style

References

  1. National Library of Medicine. Sulbactam. Medical Subject Headings (MeSH). 2026. Unique ID D013407. http://id.nlm.nih.gov/mesh/2026/D013407
  2. Sulbactam. In: Wikipedia. https://en.wikipedia.org/wiki/Sulbactam
  3. Sulbactam. In: Wikidata. https://www.wikidata.org/wiki/Q423393
  4. Sulbactam. In: PubChem Compound. CID 130313. https://pubchem.ncbi.nlm.nih.gov/compound/130313