Chemicals and Drugs

Sulindac

A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.

Chemical Identity

Chemical Information

Molecular Formula
C20H17FO3S
Molecular Weight
356.4 g/mol
CAS Registry No.
38194-50-2
IUPAC Name
2-[(3Z)-6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid
InChIKey
MLKXDPUZXIRXEP-MFOYZWKCSA-N
SMILES
CC\1=C(C2=C(/C1=C\C3=CC=C(C=C3)S(=O)C)C=CC(=C2)F)CC(=O)O
MeSH Unique ID
D013467
Source
PubChem CID 1548887

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

18 entry terms
  • Aclin
  • Apo-Sulin
  • Arthrobid
  • Arthrocine
  • Chibret
  • Clinoril
  • Copal
  • Kenalin
  • Klinoril
  • MK-231
  • Novo-Sundac
  • Nu-Sulindac
  • Sulindal
  • Apo Sulin
  • MK 231
  • MK231
  • Novo Sundac
  • Nu Sulindac

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

90(79); was see under INDENES 1979-89

MeSH Record

Previous Indexing

  • Benzene (1966-1967)
  • Benzene Derivatives (1968-1974)
  • Benzylidene Compounds (1975-1978)
  • Indenes (1966-1978)

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.426w.559w.847w.486.875w
  2. D04w.615w.486.875w

AMA Style

References

  1. National Library of Medicine. Sulindac. Medical Subject Headings (MeSH). 2026. Unique ID D013467. http://id.nlm.nih.gov/mesh/2026/D013467
  2. Sulindac. In: Wikipedia. https://en.wikipedia.org/wiki/Sulindac
  3. Sulindac. In: Wikidata. https://www.wikidata.org/wiki/Q963093
  4. Sulindac. In: PubChem Compound. CID 1548887. https://pubchem.ncbi.nlm.nih.gov/compound/1548887