Chemicals and Drugs

Sunitinib

An indole and pyrrole derivative that inhibits VEGFR-2 and PDGFR BETA RECEPTOR TYROSINE KINASES. It is used as an antineoplastic agent for the treatment of GASTROINTESTINAL STROMAL TUMORS, and for treatment of advanced or metastatic RENAL CELL CARCINOMA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An indole and pyrrole derivative that inhibits VEGFR-2 and PDGFR BETA RECEPTOR TYROSINE KINASES. It is used as an antineoplastic agent for the treatment of GASTROINTESTINAL STROMAL TUMORS, and for treatment of advanced or metastatic RENAL CELL CARCINOMA.

Chemical Identity

Chemical Information

Molecular Formula
C22H27FN4O2
Molecular Weight
398.5 g/mol
CAS Registry No.
557795-19-4
IUPAC Name
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
InChIKey
WINHZLLDWRZWRT-ATVHPVEESA-N
SMILES
CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\2/C3=C(C=CC(=C3)F)NC2=O)C
MeSH Unique ID
D000077210
Source
PubChem CID 5329102

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

9 entry terms
  • 5-(5-Fluoro-2-oxo-1,2-dihydroindolylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide
  • SU 011248
  • SU 11248
  • SU-011248
  • SU-11248
  • SU011248
  • SU11248
  • Sunitinib Malate
  • Sutent

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (2003)

MeSH Hierarchy

Tree Numbers

  1. D03w.383.129w.578.823w
  2. D03w.633.100.473.877w

AMA Style

References

  1. National Library of Medicine. Sunitinib. Medical Subject Headings (MeSH). 2026. Unique ID D000077210. http://id.nlm.nih.gov/mesh/2026/D000077210
  2. Sunitinib. In: Wikipedia. https://en.wikipedia.org/wiki/Sunitinib
  3. Sunitinib. In: Wikidata. https://www.wikidata.org/wiki/Q417542
  4. Sunitinib. In: PubChem Compound. CID 5329102. https://pubchem.ncbi.nlm.nih.gov/compound/5329102