Analytical, Diagnostic and Therapeutic Techniques, and Equipment

Surface Plasmon Resonance

A biosensing technique in which biomolecules capable of binding to specific analytes or ligands are first immobilized on one side of a metallic film. Light is then focused on the opposite side of the film to excite the surface plasmons, that is, the oscillations of free electrons propagating along the film's surface. The refractive index of light reflecting off this surface is measured. When the immobilized biomolecules are bound by their ligands, an alteration in surface plasmons on the opposite side of the film is created which is directly proportional to the change in bound, or adsorbed, mass. Binding is measured by changes in the refractive index. The technique is used to study biomolecular interactions, such as antigen-antibody binding.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A biosensing technique in which biomolecules capable of binding to specific analytes or ligands are first immobilized on one side of a metallic film. Light is then focused on the opposite side of the film to excite the surface plasmons, that is, the oscillations of free electrons propagating along the film's surface. The refractive index of light reflecting off this surface is measured. When the immobilized biomolecules are bound by their ligands, an alteration in surface plasmons on the opposite side of the film is created which is directly proportional to the change in bound, or adsorbed, mass. Binding is measured by changes in the refractive index. The technique is used to study biomolecular interactions, such as antigen-antibody binding.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

5 entry terms
  • Plasmon Resonance, Surface
  • Plasmon Resonances, Surface
  • Resonance, Surface Plasmon
  • Resonances, Surface Plasmon
  • Surface Plasmon Resonances

MeSH Record

Aspects Covered

10 allowable subheadings

Indexed with the subheadings classification, economics, ethics, history, instrumentation, methods, standards, statistics & numerical data, trends, veterinary.

MeSH Record

Indexing Annotation

do not confuse with plasmon, extrachromosomal genetic material

MeSH Record

History Note

1999

MeSH Record

Previous Indexing

  • Biosensing Techniques (1991-1998)

MeSH Hierarchy

Tree Numbers

  1. E05.196w.890w
  2. E05.601.043w.700w

MeSH Record

NLM Classification

QT 36.4

AMA Style

References

  1. National Library of Medicine. Surface Plasmon Resonance. Medical Subject Headings (MeSH). 2026. Unique ID D020349. http://id.nlm.nih.gov/mesh/2026/D020349
  2. Surface Plasmon Resonance. In: Wikipedia. https://en.wikipedia.org/wiki/Surface_plasmon_resonance_microscopy
  3. Surface Plasmon Resonance. In: Wikidata. https://www.wikidata.org/wiki/Q23808200