Phenomena and Processes

T-Cell Exhaustion

Progressive deterioration of T-cell function due to chronic antigen stimulation and inflammatory signals, e.g., CHRONIC INFECTION and CANCER. T-cell exhaustion is characterized by weakened immune system, e.g., dysfunctional MEMORY T CELLS differentiation and EPIGENETIC REPRESSION of IMMUNOLOGIC MEMORY effector functions.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Progressive deterioration of T-cell function due to chronic antigen stimulation and inflammatory signals, e.g., CHRONIC INFECTION and CANCER. T-cell exhaustion is characterized by weakened immune system, e.g., dysfunctional MEMORY T CELLS differentiation and EPIGENETIC REPRESSION of IMMUNOLOGIC MEMORY effector functions.

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Classification

Broader headings

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See Also

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Synonyms

7 entry terms
  • T-Lymphocyte Exhaustion
  • Exhaustion, T-Cell
  • Exhaustion, T-Lymphocyte
  • Exhaustions, T-Lymphocyte
  • T Cell Exhaustion
  • T Lymphocyte Exhaustion
  • T-Lymphocyte Exhaustions

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2023

MeSH Hierarchy

Tree Number

  1. G12.590.500

AMA Style

References

  1. National Library of Medicine. T-Cell Exhaustion. Medical Subject Headings (MeSH). 2026. Unique ID D000094383. http://id.nlm.nih.gov/mesh/2026/D000094383
  2. T-Cell Exhaustion. In: Wikidata. https://www.wikidata.org/wiki/Q56649209