Chemicals and Drugs

Tartrate-Resistant Acid Phosphatase

One of several acid phosphatases in humans, other mammals, plants, and a few prokaryotes. The protein fold of tartrate-resistant acid phosphatase (TRAP) resembles that of the catalytic domain of plant purple acid phosphatase and other serine/threonine-protein phosphatases that also contain a metallophosphoesterase domain. One gene produces the various forms which include purple acid phosphatases from spleen and other tissues. Tartrate-resistant acid phosphatase is a biomarker for pathological states in which it is over-expressed. Such conditions include GAUCHER DISEASE; HODGKIN DISEASE; BONE RESORPTION; and NEOPLASM METASTASIS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

One of several acid phosphatases in humans, other mammals, plants, and a few prokaryotes. The protein fold of tartrate-resistant acid phosphatase (TRAP) resembles that of the catalytic domain of plant purple acid phosphatase and other serine/threonine-protein phosphatases that also contain a metallophosphoesterase domain. One gene produces the various forms which include purple acid phosphatases from spleen and other tissues. Tartrate-resistant acid phosphatase is a biomarker for pathological states in which it is over-expressed. Such conditions include GAUCHER DISEASE; HODGKIN DISEASE; BONE RESORPTION; and NEOPLASM METASTASIS.

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Classification

Broader headings

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MeSH Record

Synonyms

14 entry terms
  • TRAcP
  • Acid Phosphatase, Tartrate-Resistant
  • Phosphatase, Tartrate-Resistant Acid
  • Tartrate Resistant Acid Phosphatase
  • AcPase V
  • Acid Phosphatase V
  • TRAP Type 5 AcPase
  • Tartrate-Resistant Acid Phosphatase Type 5
  • Type 5 Acid Phosphatase
  • Uteroferrin
  • Phosphatase V, Acid
  • Tartrate Resistant Acid Phosphatase Type 5
  • V, AcPase
  • V, Acid Phosphatase

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017 (1995)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.352w.650w.025w.500
  2. D08.811w.277w.352w.650w.625w.862
  3. D12.776w.476.559w.862

AMA Style

References

  1. National Library of Medicine. Tartrate-Resistant Acid Phosphatase. Medical Subject Headings (MeSH). 2026. Unique ID D000071681. http://id.nlm.nih.gov/mesh/2026/D000071681
  2. Tartrate-Resistant Acid Phosphatase. In: Wikidata. https://www.wikidata.org/wiki/Q7686858