Chemicals and Drugs

Teprotide

A synthetic nonapeptide (Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro) which is identical to the peptide from the venom of the snake, Bothrops jararaca. It inhibits kininase II and ANGIOTENSIN I and has been proposed as an antihypertensive agent.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A synthetic nonapeptide (Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro) which is identical to the peptide from the venom of the snake, Bothrops jararaca. It inhibits kininase II and ANGIOTENSIN I and has been proposed as an antihypertensive agent.

Chemical Identity

Chemical Information

Molecular Formula
C53H76N14O12
Molecular Weight
1101.3 g/mol
CAS Registry No.
35115-60-7
IUPAC Name
(2S)-1-[(2S)-1-[(2S,3S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-1-[(2S)-3-(1H-indol-3-yl)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid
InChIKey
UUUHXMGGBIUAPW-CSCXCSGISA-N
SMILES
CC[C@H](C)[C@@H](C(=O)N1CCC[C@H]1C(=O)N2CCC[C@H]2C(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@@H]7CCC(=O)N7
MeSH Unique ID
D013722
Source
PubChem CID 443376

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

8 entry terms
  • BPP-9a
  • Bradykinin-Potentiating Peptide 9a
  • Nonapeptide-Converting Enzyme Inhibitor
  • Bradykinin Potentiating Peptide 9a
  • Enzyme Inhibitor, Nonapeptide-Converting
  • Nonapeptide Converting Enzyme Inhibitor
  • Peptide 9a, Bradykinin-Potentiating
  • SQ-20881

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(81); was see under OLIGOPEPTIDES 1981-90, was SQ 20881 see under OLIGOPEPTIDES 1975-80; SQ 20881 was see TEPROTIDE 1981-93; NONAPEPTIDE CONVERTING-ENZYME INHIBITOR was (NM) 1975-93

MeSH Record

Previous Indexing

  • Oligopeptides (1973-1974)
  • Peptides (1966-1972)
  • Snakes (1966-1972)

MeSH Hierarchy

Tree Number

  1. D12.644w.456w.810w

AMA Style

References

  1. National Library of Medicine. Teprotide. Medical Subject Headings (MeSH). 2026. Unique ID D013722. http://id.nlm.nih.gov/mesh/2026/D013722
  2. Teprotide. In: Wikipedia. https://en.wikipedia.org/wiki/Teprotide
  3. Teprotide. In: Wikidata. https://www.wikidata.org/wiki/Q7701390
  4. Teprotide. In: PubChem Compound. CID 443376. https://pubchem.ncbi.nlm.nih.gov/compound/443376