Chemicals and Drugs

Tetradecanoylphorbol Acetate

A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.

Chemical Identity

Chemical Information

Molecular Formula
C36H56O8
Molecular Weight
616.8 g/mol
CAS Registry No.
16561-29-8
IUPAC Name
[(1S,2S,6R,10S,11R,13S,14R,15R)-13-acetyloxy-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxo-14-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dienyl] tetradecanoate
InChIKey
PHEDXBVPIONUQT-RGYGYFBISA-N
SMILES
CCCCCCCCCCCCCC(=O)O[C@@H]1[C@H]([C@]2([C@@H](C=C(C[C@]3([C@H]2C=C(C3=O)C)O)CO)[C@H]4[C@@]1(C4(C)C)OC(=O)C)O)C
MeSH Unique ID
D013755
Source
PubChem CID 27924

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

12 entry terms
  • 12-Myristoyl-13-acetylphorbol
  • 12-O-Tetradecanoyl Phorbol 13-Acetate
  • Phorbol Myristate Acetate
  • 12 Myristoyl 13 acetylphorbol
  • 12 O Tetradecanoyl Phorbol 13 Acetate
  • 13-Acetate, 12-O-Tetradecanoyl Phorbol
  • Acetate, Phorbol Myristate
  • Acetate, Tetradecanoylphorbol
  • Myristate Acetate, Phorbol
  • Phorbol 13-Acetate, 12-O-Tetradecanoyl
  • Tetradecanoylphorbol Acetate, 4a alpha-Isomer
  • Tetradecanoylphorbol Acetate, 4a alpha Isomer

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

87(75); was see under PHORBOLS 1975-86

MeSH Record

Previous Indexing

  • Alcohols (1966-1974)
  • Croton Oil (1966-1974)
  • Diterpenes (1974)
  • Fatty Acids (1966-1974)
  • Terpenes (1966-1973)

MeSH Hierarchy

Tree Number

  1. D02w.455w.849w.291w.500.510w.850w

AMA Style

References

  1. National Library of Medicine. Tetradecanoylphorbol Acetate. Medical Subject Headings (MeSH). 2026. Unique ID D013755. http://id.nlm.nih.gov/mesh/2026/D013755
  2. Tetradecanoylphorbol Acetate. In: Wikipedia. https://en.wikipedia.org/wiki/12-O-Tetradecanoylphorbol-13-acetate
  3. Tetradecanoylphorbol Acetate. In: Wikidata. https://www.wikidata.org/wiki/Q416716
  4. Tetradecanoylphorbol Acetate. In: PubChem Compound. CID 27924. https://pubchem.ncbi.nlm.nih.gov/compound/27924