Structured Summary
Abstract
An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.
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Classification
Broader headings
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Synonyms
8 entry terms
- Dihydrofolate Dehydrogenase
- Dihydrofolate Reductase
- Folic Acid Reductase
- Acid Reductase, Folic
- Dehydrogenase, Dihydrofolate
- Dehydrogenase, Tetrahydrofolate
- Reductase, Dihydrofolate
- Reductase, Folic Acid
MeSH Record
Aspects Covered
28 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
66; DIHYDROFOLATE DEHYDROGENASE was heading 1966-88
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References
- National Library of Medicine. Tetrahydrofolate Dehydrogenase. Medical Subject Headings (MeSH). 2026. Unique ID D013762. http://id.nlm.nih.gov/mesh/2026/D013762
- Tetrahydrofolate Dehydrogenase. In: Wikidata. https://www.wikidata.org/wiki/Q76123647