Chemicals and Drugs

Tetrodotoxin

An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.

Chemical Identity

Chemical Information

Molecular Formula
C11H17N3O8
Molecular Weight
319.27 g/mol
IUPAC Name
(1R,5R,6R,7R,9S,11S,12R,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.17,11.01,6]tetradec-3-ene-5,9,12,13,14-pentol
InChIKey
CFMYXEVWODSLAX-QYIGHCJRSA-N
SMILES
C([C@@]1([C@H]2[C@@H]3[C@H](N=C(N[C@@]34[C@H]([C@@H]1O[C@]([C@H]4O)(O2)O)O)N)O)O)O
MeSH Unique ID
D013779
Source
PubChem CID 6324668

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

4 entry terms
  • Fugu Toxin
  • Tarichatoxin
  • Tetradotoxin
  • Toxin, Fugu

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

/antag permitted but consider also ANTITOXINS

MeSH Record

History Note

68(64)

MeSH Hierarchy

Tree Numbers

  1. D03w.633.100.786.910w
  2. D23.946w.580.910w

AMA Style

References

  1. National Library of Medicine. Tetrodotoxin. Medical Subject Headings (MeSH). 2026. Unique ID D013779. http://id.nlm.nih.gov/mesh/2026/D013779
  2. Tetrodotoxin. In: Wikipedia. https://en.wikipedia.org/wiki/Tetrodotoxin
  3. Tetrodotoxin. In: Wikidata. https://www.wikidata.org/wiki/Q379842
  4. Tetrodotoxin. In: PubChem Compound. CID 6324668. https://pubchem.ncbi.nlm.nih.gov/compound/6324668