Structured Summary
Abstract
A sesquiterpene lactone found in roots of THAPSIA. It inhibits SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES.
Chemical Identity
Chemical Information
- Molecular Formula
- C34H50O12
- Molecular Weight
- 650.8 g/mol
- CAS Registry No.
- 67526-95-8
- IUPAC Name
- [(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetyloxy-4-butanoyloxy-3,3a-dihydroxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] octanoate
- InChIKey
- IXFPJGBNCFXKPI-FSIHEZPISA-N
- SMILES
- CCCCCCCC(=O)O[C@H]1[C@H]2C(=C([C@@H]1OC(=O)/C(=C\C)/C)C)[C@H]3[C@]([C@H](C[C@]2(C)OC(=O)C)OC(=O)CCC)([C@](C(=O)O3)(C)O)O
- MeSH Unique ID
- D019284
- Source
- PubChem CID 446378
MeSH Record
Classification
Broader headings
Related Concepts
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Drug Class
Pharmacological Action
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
97; was THAPSIGARGIN (NM) 1979-96
MeSH Record
Previous Indexing
- Terpenes (1979-1996)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Thapsigargin. Medical Subject Headings (MeSH). 2026. Unique ID D019284. http://id.nlm.nih.gov/mesh/2026/D019284
- Thapsigargin. In: Wikipedia. https://en.wikipedia.org/wiki/Thapsigargin
- Thapsigargin. In: Wikidata. https://www.wikidata.org/wiki/Q3981006
- Thapsigargin. In: PubChem Compound. CID 446378. https://pubchem.ncbi.nlm.nih.gov/compound/446378