Structured Summary
Abstract
A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
Chemical Identity
Chemical Information
- Molecular Formula
- C12H15NO3S
- Molecular Weight
- 253.32 g/mol
- CAS Registry No.
- 76721-89-6
- IUPAC Name
- 2-[(2-benzyl-3-sulfanylpropanoyl)amino]acetic acid
- InChIKey
- LJJKNPQAGWVLDQ-UHFFFAOYSA-N
- SMILES
- C1=CC=C(C=C1)CC(CS)C(=O)NCC(=O)O
- MeSH Unique ID
- D015244
- Source
- PubChem CID 3132
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
4 entry terms
- (3-Mercapto-2-benzylpropionyl)glycine
- Tiorphan
- Thiorphan, (R)-Isomer
- Thiorphan, (S)-Isomer
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
89
MeSH Record
Previous Indexing
- Mercaptopropionylglycine/analogs & derivatives (1980-1988)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Thiorphan. Medical Subject Headings (MeSH). 2026. Unique ID D015244. http://id.nlm.nih.gov/mesh/2026/D015244
- Thiorphan. In: Wikipedia. https://en.wikipedia.org/wiki/Thiorphan
- Thiorphan. In: Wikidata. https://www.wikidata.org/wiki/Q7784695
- Thiorphan. In: PubChem Compound. CID 3132. https://pubchem.ncbi.nlm.nih.gov/compound/3132