Chemicals and Drugs

Threonine Dehydratase

A pyridoxal-phosphate protein that catalyzes the deamination of THREONINE to 2-ketobutyrate and AMMONIA. The role of this enzyme can be biosynthetic or biodegradative. In the former role it supplies 2-ketobutyrate required for ISOLEUCINE biosynthesis, while in the latter it is only involved in the breakdown of threonine to supply energy. This enzyme was formerly listed as EC 4.2.1.16.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A pyridoxal-phosphate protein that catalyzes the deamination of THREONINE to 2-ketobutyrate and AMMONIA. The role of this enzyme can be biosynthetic or biodegradative. In the former role it supplies 2-ketobutyrate required for ISOLEUCINE biosynthesis, while in the latter it is only involved in the breakdown of threonine to supply energy. This enzyme was formerly listed as EC 4.2.1.16.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

8 entry terms
  • Threonine Ammonia-Lyase
  • Threonine Deaminase
  • Threonine Dehydrase
  • Ammonia-Lyase, Threonine
  • Deaminase, Threonine
  • Dehydrase, Threonine
  • Dehydratase, Threonine
  • Threonine Ammonia Lyase

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

78(75); was see under HYDRO-LYASES 1975-77

MeSH Record

Previous Indexing

  • Hydro-Lyases (1966-1974)
  • Threonine (1966-1974)

MeSH Hierarchy

Tree Number

AMA Style

References

  1. National Library of Medicine. Threonine Dehydratase. Medical Subject Headings (MeSH). 2026. Unique ID D013913. http://id.nlm.nih.gov/mesh/2026/D013913
  2. Threonine Dehydratase. In: Wikipedia. https://en.wikipedia.org/wiki/Threonine_ammonia-lyase
  3. Threonine Dehydratase. In: Wikidata. https://www.wikidata.org/wiki/Q3525998