Chemicals and Drugs

Thrombospondins

A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.

MeSH Record

Classification

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MeSH Record

Synonyms

1 entry terms
  • Thrombospondin

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

membrane glycoproteins; THROMBOSPONDIN 1 is also available

MeSH Record

History Note

98; see THROMBOSPONDINS (NM) 1981-97

MeSH Record

Previous Indexing

  • Glycoproteins (1981-1989)
  • Membrane Glycoproteins (1989-1997)
  • Platelet Membrane Glycoproteins (1992-1993)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.430w.890w.895w
  2. D12.776w.395w.550w.895w
  3. D12.776w.543w.550w.895w

AMA Style

References

  1. National Library of Medicine. Thrombospondins. Medical Subject Headings (MeSH). 2026. Unique ID D019699. http://id.nlm.nih.gov/mesh/2026/D019699
  2. Thrombospondins. In: Wikipedia. https://en.wikipedia.org/wiki/Thrombospondin
  3. Thrombospondins. In: Wikidata. https://www.wikidata.org/wiki/Q419341