Structured Summary
Abstract
An acquired, congenital, or familial disorder caused by PLATELET AGGREGATION with THROMBOSIS in terminal arterioles and capillaries. Clinical features include THROMBOCYTOPENIA; HEMOLYTIC ANEMIA; AZOTEMIA; FEVER; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as RENAL FAILURE. Mutations in the ADAMTS13 PROTEIN gene have been identified in familial cases.
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Synonyms
21 entry terms
- Moschcowitz Disease
- Moschkowitz Disease
- Purpura, Thrombotic Thrombocytopenic
- Purpura, Thrombotic Thrombopenic
- Thrombocytopenic Purpura, Thrombotic
- Thrombopenic Purpura, Thrombotic
- Thrombotic Thrombopenic Purpura
- Congenital Thrombotic Thrombocytopenic Purpura
- Familial Thrombotic Thrombocytopenia Purpura
- Familial Thrombotic Thrombocytopenic Purpura
- Microangiopathic Hemolytic Anemia, Congenital
- Schulman-Upshaw Syndrome
- Thrombotic Microangiopathy, Familial
- Thrombotic Thrombocytopenic Purpura, Congenital
- Thrombotic Thrombocytopenic Purpura, Familial
- Upshaw Factor, Deficiency of
- Upshaw-Schulman Syndrome
- Familial Thrombotic Microangiopathy
- Microangiopathy, Familial Thrombotic
- Schulman Upshaw Syndrome
- Upshaw Schulman Syndrome
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Aspects Covered
35 allowable subheadings
Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.
MeSH Record
History Note
1986; use PURPURA, THROMBOTIC THROMBOPENIC 1965-1985
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AMA Style
References
- National Library of Medicine. Thrombotic Thrombocytopenic Purpura. Medical Subject Headings (MeSH). 2026. Unique ID D011697. http://id.nlm.nih.gov/mesh/2026/D011697
- Thrombotic Thrombocytopenic Purpura. In: Wikipedia. https://en.wikipedia.org/wiki/Thrombotic_thrombocytopenic_purpura
- Thrombotic Thrombocytopenic Purpura. In: Wikidata. https://www.wikidata.org/wiki/Q1426491