Chemicals and Drugs

Thromboxane A2

An unstable intermediate between the prostaglandin endoperoxides and thromboxane B2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance (RCS).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An unstable intermediate between the prostaglandin endoperoxides and thromboxane B2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance (RCS).

Chemical Identity

Chemical Information

Molecular Formula
C20H32O5
Molecular Weight
352.5 g/mol
CAS Registry No.
57576-52-0
IUPAC Name
(Z)-7-[(1S,3R,4S,5S)-3-[(E,3S)-3-hydroxyoct-1-enyl]-2,6-dioxabicyclo[3.1.1]heptan-4-yl]hept-5-enoic acid
InChIKey
DSNBHJFQCNUKMA-SCKDECHMSA-N
SMILES
CCCCC[C@@H](/C=C/[C@@H]1[C@H]([C@@H]2C[C@@H](O2)O1)C/C=C\CCCC(=O)O)O
MeSH Unique ID
D013928
Source
PubChem CID 5280497

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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MeSH Record

Synonyms

2 entry terms
  • A2, Thromboxane
  • Rabbit Aorta Contracting Substance

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

/biosyn /physiol permitted

MeSH Record

History Note

86(78); was see under THROMBOXANES 1978-85

MeSH Record

Previous Indexing

  • Fatty Acids, Unsaturated (1973-1974)
  • Hydroxy Acids (1975-1977)
  • Pyrans (1966-1977)

MeSH Hierarchy

Tree Numbers

  1. D10w.251w.355w.255w.100.825w.800w
  2. D10w.251w.355w.310w.166.971w.800w

MeSH Record

NLM Classification

QU 90

AMA Style

References

  1. National Library of Medicine. Thromboxane A2. Medical Subject Headings (MeSH). 2026. Unique ID D013928. http://id.nlm.nih.gov/mesh/2026/D013928
  2. Thromboxane A2. In: Wikipedia. https://en.wikipedia.org/wiki/Thromboxane_A2
  3. Thromboxane A2. In: Wikidata. https://www.wikidata.org/wiki/Q774909
  4. Thromboxane A2. In: PubChem Compound. CID 5280497. https://pubchem.ncbi.nlm.nih.gov/compound/5280497