Chemicals and Drugs

Thymidylate Synthase

An enzyme of the transferase class that catalyzes the reaction 5,10-methylenetetrahydrofolate and dUMP to dihydrofolate and dTMP in the synthesis of thymidine triphosphate. (From Dorland, 27th ed) EC 2.1.1.45.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An enzyme of the transferase class that catalyzes the reaction 5,10-methylenetetrahydrofolate and dUMP to dihydrofolate and dTMP in the synthesis of thymidine triphosphate. (From Dorland, 27th ed) EC 2.1.1.45.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

3 entry terms
  • Thymidylate Synthetase
  • Synthase, Thymidylate
  • Synthetase, Thymidylate

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

1998; see METHYLTRANSFERASES 1975-1985

MeSH Record

Previous Indexing

  • Ligases (1966-1970)
  • Methyltransferases (1971-1972)
  • Transferases (1969-1972)

MeSH Hierarchy

Tree Number

  1. D08.811w.913w.555.500w.862

AMA Style

References

  1. National Library of Medicine. Thymidylate Synthase. Medical Subject Headings (MeSH). 2026. Unique ID D013940. http://id.nlm.nih.gov/mesh/2026/D013940
  2. Thymidylate Synthase. In: Wikidata. https://www.wikidata.org/wiki/Q24786423