Structured Summary
Abstract
A homeobox protein and transcription factor that localizes to the cell nucleus where it activates expression of thyroid specific genes such as THYROGLOBULIN and the THYROTROPIN RECEPTOR. It is critical for maintaining thyroid tissue in a differentiated state and also plays a role in lung development. Mutations in the NKX2-1 gene are associated with CHOREA, BENIGN HEREDITARY.
MeSH Record
Classification
Broader headings
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MeSH Record
Synonyms
13 entry terms
- Homeobox Protein Nkx-2.1
- NK2 Homeobox 1 Protein
- TITF-1 Protein
- TITF1 Protein
- TTF-1 Thyroid Nuclear Factor
- Thyroid Transcription Factor 1
- Thyroid-Specific Enhancer-Binding Protein
- Enhancer-Binding Protein, Thyroid-Specific
- Homeobox Protein Nkx 2.1
- Nkx-2.1, Homeobox Protein
- TITF 1 Protein
- TTF 1 Thyroid Nuclear Factor
- Thyroid Specific Enhancer Binding Protein
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2018 (1990)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Thyroid Nuclear Factor 1. Medical Subject Headings (MeSH). 2026. Unique ID D000074482. http://id.nlm.nih.gov/mesh/2026/D000074482
- Thyroid Nuclear Factor 1. In: Wikipedia. https://en.wikipedia.org/wiki/NK2_homeobox_1
- Thyroid Nuclear Factor 1. In: Wikidata. https://www.wikidata.org/wiki/Q21109009