Chemicals and Drugs

Ticagrelor

An adenosine triphosphate analogue and reversible P2Y12 PURINORECEPTOR antagonist that inhibits ADP-mediated PLATELET AGGREGATION. It is used for the prevention of THROMBOEMBOLISM by patients with ACUTE CORONARY SYNDROME or a history of MYOCARDIAL INFARCTION.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An adenosine triphosphate analogue and reversible P2Y12 PURINORECEPTOR antagonist that inhibits ADP-mediated PLATELET AGGREGATION. It is used for the prevention of THROMBOEMBOLISM by patients with ACUTE CORONARY SYNDROME or a history of MYOCARDIAL INFARCTION.

Chemical Identity

Chemical Information

Molecular Formula
C23H28F2N6O4S
Molecular Weight
522.6 g/mol
CAS Registry No.
274693-27-5
IUPAC Name
(1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-propylsulfanyltriazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol
InChIKey
OEKWJQXRCDYSHL-FNOIDJSQSA-N
SMILES
CCCSC1=NC(=C2C(=N1)N(N=N2)[C@@H]3C[C@@H]([C@H]([C@H]3O)O)OCCO)N[C@@H]4C[C@H]4C5=CC(=C(C=C5)F)F
MeSH Unique ID
D000077486
Source
PubChem CID 9871419

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

6 entry terms
  • 3-(7-((2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-(1-3)-triazolo(4,5-d)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol
  • AZD 6140
  • AZD-6140
  • AZD6140
  • Brilinta
  • Brilique

MeSH Record

Aspects Covered

24 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (2005)

MeSH Hierarchy

Tree Numbers

  1. D03w.633.100.759.590.138w.806w
  2. D13.570w.583.138w.806w
  3. D13.570w.800w.096w.815w

AMA Style

References

  1. National Library of Medicine. Ticagrelor. Medical Subject Headings (MeSH). 2026. Unique ID D000077486. http://id.nlm.nih.gov/mesh/2026/D000077486
  2. Ticagrelor. In: Wikipedia. https://en.wikipedia.org/wiki/Ticagrelor
  3. Ticagrelor. In: Wikidata. https://www.wikidata.org/wiki/Q420542
  4. Ticagrelor. In: PubChem Compound. CID 9871419. https://pubchem.ncbi.nlm.nih.gov/compound/9871419