Structured Summary
Abstract
A triazine derivative that introduces breaks into DNA strands in hypoxic cells, sensitizing tumor cells to the cytotoxic activity of other drugs and radiation.
Chemical Identity
Chemical Information
- Molecular Formula
- C7H6N4O2
- Molecular Weight
- 178.15 g/mol
- CAS Registry No.
- 27314-97-2
- IUPAC Name
- 1,4-dioxido-1,2,4-benzotriazine-1,4-diium-3-amine
- InChIKey
- ORYDPOVDJJZGHQ-UHFFFAOYSA-N
- SMILES
- C1=CC=C2C(=C1)[N+](=C(N=[N+]2[O-])N)[O-]
- MeSH Unique ID
- D000077704
- Source
- PubChem CID 135413511
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
9 entry terms
- 3-Amino-1,2,4-benzotriazine-1,4-dioxide
- NSC 130181
- SR 4233
- SR-4233
- Tirazone
- WIN 59075
- WIN-59075
- SR4233
- WIN59075
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2019 (1986)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Tirapazamine. Medical Subject Headings (MeSH). 2026. Unique ID D000077704. http://id.nlm.nih.gov/mesh/2026/D000077704
- Tirapazamine. In: Wikipedia. https://en.wikipedia.org/wiki/Tirapazamine
- Tirapazamine. In: Wikidata. https://www.wikidata.org/wiki/Q3529346
- Tirapazamine. In: PubChem Compound. CID 135413511. https://pubchem.ncbi.nlm.nih.gov/compound/135413511