Chemicals and Drugs

Topotecan

An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.

Chemical Identity

Chemical Information

Molecular Formula
C23H23N3O5
Molecular Weight
421.4 g/mol
CAS Registry No.
123948-87-8
IUPAC Name
(19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
InChIKey
UCFGDBYHRUNTLO-QHCPKHFHSA-N
SMILES
CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O
MeSH Unique ID
D019772
Source
PubChem CID 60700

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

18 entry terms
  • 9-Dimethylaminomethyl-10-hydroxycamptothecin
  • 9 Dimethylaminomethyl 10 hydroxycamptothecin
  • Hycamtamine
  • Hycamtin
  • NSC-609699
  • Nogitecan Hydrochloride
  • SK&F-104864-A
  • SKF-104864-A
  • Topotecan Hydrochloride
  • Topotecan Monohydrochloride, (S)-Isomer
  • Hydrochloride, Nogitecan
  • Hydrochloride, Topotecan
  • NSC 609699
  • NSC609699
  • SK&F 104864 A
  • SK&F104864A
  • SKF 104864 A
  • SKF104864A

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

98; use TOPOTECAN (NM) 1991-97

MeSH Record

Previous Indexing

  • Camptothecin/analogs & derivatives (1991-1997)

MeSH Hierarchy

Tree Number

  1. D03w.132w.151w.850w

AMA Style

References

  1. National Library of Medicine. Topotecan. Medical Subject Headings (MeSH). 2026. Unique ID D019772. http://id.nlm.nih.gov/mesh/2026/D019772
  2. Topotecan. In: Wikipedia. https://en.wikipedia.org/wiki/Topotecan
  3. Topotecan. In: Wikidata. https://www.wikidata.org/wiki/Q419953
  4. Topotecan. In: PubChem Compound. CID 60700. https://pubchem.ncbi.nlm.nih.gov/compound/60700