Chemicals and Drugs

Toxiferine

A curare alkaloid that is a very potent competitive nicotinic antagonist at the neuromuscular junction.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A curare alkaloid that is a very potent competitive nicotinic antagonist at the neuromuscular junction.

Chemical Identity

Chemical Information

Molecular Formula
C40H46N4O2+2
Molecular Weight
614.8 g/mol
CAS Registry No.
302-30-7
IUPAC Name
(2E)-2-[(1S,9Z,11S,13S,14S,17S,25Z,27S,30S,33S,35S,36S,38E)-38-(2-hydroxyethylidene)-14,30-dimethyl-8,24-diaza-14,30-diazoniaundecacyclo[25.5.2.211,14.11,26.110,17.02,7.013,17.018,23.030,33.08,35.024,36]octatriaconta-2,4,6,9,18,20,22,25-octaen-28-ylidene]ethanol
InChIKey
IIYHWTVUYIYKKG-QQRSFBQTSA-N
SMILES
C[N@@+]12[C@@H]3[C@]4(C5=CC=CC=C5N/6[C@H]4/C(=C\N7[C@H]8/C(=C6)/[C@@H]9/C(=C\CO)/C[N@+]4([C@H]([C@]8(C5=CC=CC=C75)CC4)C9)C)/[C@@H](C3)/C(=C\CO)/C1)CC2
MeSH Unique ID
D014117
Source
PubChem CID 5281411

MeSH Record

Classification

Broader headings

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Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Aspects Covered

27 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

a neuromusc nondepolarizing agent

MeSH Record

History Note

63; CALABASH CURARE was see TOXIFERINE 1966-94

MeSH Hierarchy

Tree Numbers

  1. D02w.092w.877.844w
  2. D02w.675w.276.844w
  3. D03w.132w.098.833w
  4. D03w.633.100.531.085.777w
  5. D03w.633.100.531.820.687w

AMA Style

References

  1. National Library of Medicine. Toxiferine. Medical Subject Headings (MeSH). 2026. Unique ID D014117. http://id.nlm.nih.gov/mesh/2026/D014117
  2. Toxiferine. In: Wikipedia. https://en.wikipedia.org/wiki/Toxiferine
  3. Toxiferine. In: Wikidata. https://www.wikidata.org/wiki/Q392418
  4. Toxiferine. In: PubChem Compound. CID 5281411. https://pubchem.ncbi.nlm.nih.gov/compound/5281411