Chemicals and Drugs

Trabectedin

A complex structure that includes isoquinolines joined by a cyclic ester; it is a DNA-binding agent and guanine N2 alkylator derived from the marine tunicate, Ecteinascidia turbinata. Trabectedin is used for the treatment of advanced soft-tissue SARCOMA, after failure of ANTHRACYCLINES or IFOSFAMIDE drug therapy.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A complex structure that includes isoquinolines joined by a cyclic ester; it is a DNA-binding agent and guanine N2 alkylator derived from the marine tunicate, Ecteinascidia turbinata. Trabectedin is used for the treatment of advanced soft-tissue SARCOMA, after failure of ANTHRACYCLINES or IFOSFAMIDE drug therapy.

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

6 entry terms
  • ET 743
  • ET-743
  • Ecteinascidin 743
  • NSC 684766
  • Yondelis
  • ET743

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1996)

MeSH Hierarchy

Tree Numbers

  1. D03w.383.246.619w
  2. D03w.633.100.531.820.781w

AMA Style

References

  1. National Library of Medicine. Trabectedin. Medical Subject Headings (MeSH). 2026. Unique ID D000077606. http://id.nlm.nih.gov/mesh/2026/D000077606
  2. Trabectedin. In: Wikipedia. https://en.wikipedia.org/wiki/Trabectedin
  3. Trabectedin. In: Wikidata. https://www.wikidata.org/wiki/Q2637746