Structured Summary
Abstract
A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder.
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Classification
Broader headings
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Synonyms
7 entry terms
- TCF-4 Protein
- TCF-4 Transcription Factor
- TCF4 Transcription Factor
- TCF 4 Protein
- TCF 4 Transcription Factor
- Transcription Factor, TCF-4
- Transcription Factor, TCF4
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2018
MeSH Record
Previous Indexing
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors (2010-2017)
- Transcription Factors (2008-2017)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Transcription Factor 4. Medical Subject Headings (MeSH). 2026. Unique ID D000073940. http://id.nlm.nih.gov/mesh/2026/D000073940
- Transcription Factor 4. In: Wikidata. https://www.wikidata.org/wiki/Q7669683