Chemicals and Drugs

Transforming Growth Factor beta

A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.

MeSH Record

Classification

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MeSH Record

Synonyms

8 entry terms
  • Bone-Derived Transforming Growth Factor
  • Milk Growth Factor
  • Platelet Transforming Growth Factor
  • TGF-beta
  • TGFbeta
  • Bone Derived Transforming Growth Factor
  • Factor, Milk Growth
  • Growth Factor, Milk

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91; was see TRANSFORMING GROWTH FACTORS 1989-90; TGF-BETA was see TRANSFORMING GROWTH FACTORS 1989-90

MeSH Record

Previous Indexing

  • Peptides (1983-1988)
  • Transforming Growth Factors (1989-1990)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.276.374w.687w
  2. D12.644w.276.954.775w
  3. D12.776w.467.374w.687w
  4. D12.776w.467.942.775w
  5. D23.529.374w.687w
  6. D23.529.942.775w

MeSH Record

NLM Classification

QU 107

AMA Style

References

  1. National Library of Medicine. Transforming Growth Factor beta. Medical Subject Headings (MeSH). 2026. Unique ID D016212. http://id.nlm.nih.gov/mesh/2026/D016212
  2. Transforming Growth Factor beta. In: Wikipedia. https://en.wikipedia.org/wiki/Transforming_growth_factor_beta
  3. Transforming Growth Factor beta. In: Wikidata. https://www.wikidata.org/wiki/Q24785672