Chemicals and Drugs

Transforming Protein 1 Src Homology 2 Domain-Containing

An SHC-signaling adaptor protein that transduces PHOSPHOTYROSINE-dependent signals downstream of RECEPTOR PROTEIN-TYROSINE KINASES and non-receptor tyrosine kinases. It is required for TGF-BETA-induced CELL MIGRATION; NEOLPASM INVASION; and METASTASIS of BREAST NEOPLASMS; its SH2 DOMAIN is essential for tumor survival. It also functions in signaling downstream of ANGIOPOIETIN RECEPTOR TIE-2, regulating the migration of ENDOTHELIAL CELLS; and PHYSIOLOGIC NEOVASCULARIZATION.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An SHC-signaling adaptor protein that transduces PHOSPHOTYROSINE-dependent signals downstream of RECEPTOR PROTEIN-TYROSINE KINASES and non-receptor tyrosine kinases. It is required for TGF-BETA-induced CELL MIGRATION; NEOLPASM INVASION; and METASTASIS of BREAST NEOPLASMS; its SH2 DOMAIN is essential for tumor survival. It also functions in signaling downstream of ANGIOPOIETIN RECEPTOR TIE-2, regulating the migration of ENDOTHELIAL CELLS; and PHYSIOLOGIC NEOVASCULARIZATION.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

10 entry terms
  • SHC (Src Homology 2 Domain-Containing) Transforming Protein 1
  • SHC-Transforming Protein 1
  • SHC1 (Src Homology 2 Domain-Containing) Protein
  • SHC1 Protein
  • ShcA Protein
  • Src Homology 2 Domain-Containing, Transforming Protein 1
  • Src Homology 2 Domain-Containing-Transforming Protein C1
  • SHC Transforming Protein 1
  • Src Homology 2 Domain Containing Transforming Protein C1
  • Src Homology 2 Domain Containing, Transforming Protein 1

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017; use SHC SIGNALING ADAPTOR PROTEINS 2009-2016

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.024w.330.500
  2. D12.776w.157w.057w.162.500
  3. D12.776w.476.024w.424.500

AMA Style

References

  1. National Library of Medicine. Transforming Protein 1 Src Homology 2 Domain-Containing. Medical Subject Headings (MeSH). 2026. Unique ID D000071425. http://id.nlm.nih.gov/mesh/2026/D000071425
  2. Transforming Protein 1 Src Homology 2 Domain-Containing. In: Wikidata. https://www.wikidata.org/wiki/Q21116165