Chemicals and Drugs

Transglutaminases

Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.

MeSH Record

Classification

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MeSH Record

Synonyms

7 entry terms
  • Glutaminyl-Peptide Gamma-Glutamyltransferases
  • Protein-Glutamine gamma-Glutamyltransferases
  • Transglutaminase
  • Gamma-Glutamyltransferases, Glutaminyl-Peptide
  • Glutaminyl Peptide Gamma Glutamyltransferases
  • Protein Glutamine gamma Glutamyltransferases
  • gamma-Glutamyltransferases, Protein-Glutamine

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

distinguish entry terms GLUTAMINYL-PEPTIDE GAMMA-GLUTAMYLTRANSFERASES, and TRANSGLUTAMINASES from GAMMA-GLUTAMYL TRANSPEPTIDASE which is involved with glutathione metabolism; PLASMA TRANSGLUTAMINASE see FACTOR XIIIA is also available

MeSH Record

History Note

2002(1986)

MeSH Record

Previous Indexing

  • Acyltransferases (1966-1985)

MeSH Hierarchy

Tree Number

  1. D08.811w.913w.050w.200w.800w

AMA Style

References

  1. National Library of Medicine. Transglutaminases. Medical Subject Headings (MeSH). 2026. Unique ID D011503. http://id.nlm.nih.gov/mesh/2026/D011503
  2. Transglutaminases. In: Wikipedia. https://en.wikipedia.org/wiki/Transglutaminase
  3. Transglutaminases. In: Wikidata. https://www.wikidata.org/wiki/Q423646