Structured Summary
Abstract
A family of small peptides expressed primarily by MUCOUS MEMBRANE EPITHELIAL CELLS in vertebrates. Their structure is highly conserved and is defined by a three-leaved (trefoil) domain of 42 or 43 amino acids; it includes six cysteines that create the trefoil structure through disulfide bridges. Trefoil peptides may form dimers with each other, or associate with MUCINS and other factors. They are important for maintaining epithelial integrity and for protection from noxious agents.
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Synonyms
13 entry terms
- TFF Peptide
- TFF Peptides
- Trefoil Factor
- Trefoil Factor Family Peptides
- Trefoil Factor Family Proteins
- Trefoil Peptide
- Trefoil Peptides
- Trefoil Protein
- Trefoil Proteins
- Factor, Trefoil
- Peptide, TFF
- Peptide, Trefoil
- Protein, Trefoil
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2017
MeSH Record
Previous Indexing
- Mucins (1992-2016)
- Peptides (1992-2016)
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AMA Style
References
- National Library of Medicine. Trefoil Factors. Medical Subject Headings (MeSH). 2026. Unique ID D000071162. http://id.nlm.nih.gov/mesh/2026/D000071162
- Trefoil Factors. In: Wikidata. https://www.wikidata.org/wiki/Q76852218