Chemicals and Drugs

Tretinoin

An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).

Chemical Identity

Chemical Information

Molecular Formula
C20H28O2
Molecular Weight
300.4 g/mol
CAS Registry No.
302-79-4
IUPAC Name
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
InChIKey
SHGAZHPCJJPHSC-YCNIQYBTSA-N
SMILES
CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C(=O)O)/C)/C
MeSH Unique ID
D014212
Source
PubChem CID 444795

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

25 entry terms
  • Retinoic Acid
  • Vitamin A Acid
  • all-trans-Retinoic Acid
  • trans-Retinoic Acid
  • Acid, Retinoic
  • Acid, Vitamin A
  • Acid, all-trans-Retinoic
  • Acid, trans-Retinoic
  • all trans Retinoic Acid
  • trans Retinoic Acid
  • Retin-A
  • Tretinoin Potassium Salt
  • Tretinoin Sodium Salt
  • Tretinoin Zinc Salt
  • Vesanoid
  • beta-all-trans-Retinoic Acid
  • Acid, beta-all-trans-Retinoic
  • Potassium Salt, Tretinoin
  • Retin A
  • Salt, Tretinoin Potassium
  • Salt, Tretinoin Sodium
  • Salt, Tretinoin Zinc
  • Sodium Salt, Tretinoin
  • Zinc Salt, Tretinoin
  • beta all trans Retinoic Acid

MeSH Record

Aspects Covered

26 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

80(75); was see under VITAMIN A 1975-79

MeSH Record

Previous Indexing

  • Carotenoids (1969-1974)
  • Vitamin A (1966-1974)

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.326.271w.665w.202w.495w.818w.500w
  2. D02w.455w.426w.392.368w.367.379.249w.700w.860w.500w
  3. D02w.455w.849w.131w.495w.818w.800w
  4. D02w.455w.849w.291w.925w.500w
  5. D23.767w.261w.700w.780w

AMA Style

References

  1. National Library of Medicine. Tretinoin. Medical Subject Headings (MeSH). 2026. Unique ID D014212. http://id.nlm.nih.gov/mesh/2026/D014212
  2. Tretinoin. In: Wikipedia. https://en.wikipedia.org/wiki/Tretinoin
  3. Tretinoin. In: Wikidata. https://www.wikidata.org/wiki/Q29417
  4. Tretinoin. In: PubChem Compound. CID 444795. https://pubchem.ncbi.nlm.nih.gov/compound/444795