Chemicals and Drugs

Triazolam

A short-acting benzodiazepine used in the treatment of insomnia. Some countries temporarily withdrew triazolam from the market because of concerns about adverse reactions, mostly psychological, associated with higher dose ranges. Its use at lower doses with appropriate care and labeling has been reaffirmed by the FDA and most other countries.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A short-acting benzodiazepine used in the treatment of insomnia. Some countries temporarily withdrew triazolam from the market because of concerns about adverse reactions, mostly psychological, associated with higher dose ranges. Its use at lower doses with appropriate care and labeling has been reaffirmed by the FDA and most other countries.

Chemical Identity

Chemical Information

Molecular Formula
C17H12Cl2N4
Molecular Weight
343.2 g/mol
CAS Registry No.
28911-01-5
IUPAC Name
8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
InChIKey
JOFWLTCLBGQGBO-UHFFFAOYSA-N
SMILES
CC1=NN=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4Cl
MeSH Unique ID
D014229
Source
PubChem CID 5556

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

9 entry terms
  • Apo-Triazo
  • Gen-Triazolam
  • Halcion
  • Trilam
  • U-33,030
  • Apo Triazo
  • Gen Triazolam
  • U 33,030
  • U33,030

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

86(77); was see under BENZODIAZEPINE TRANQUILIZERS 1977-85

MeSH Record

Previous Indexing

  • Benzazepines (1974)
  • Benzodiazepines (1975-1976)
  • Triazoles (1974-1976)

MeSH Hierarchy

Tree Number

  1. D03w.633.100.079.080w.900w

AMA Style

References

  1. National Library of Medicine. Triazolam. Medical Subject Headings (MeSH). 2026. Unique ID D014229. http://id.nlm.nih.gov/mesh/2026/D014229
  2. Triazolam. In: Wikipedia. https://en.wikipedia.org/wiki/Triazolam
  3. Triazolam. In: Wikidata. https://www.wikidata.org/wiki/Q412143
  4. Triazolam. In: PubChem Compound. CID 5556. https://pubchem.ncbi.nlm.nih.gov/compound/5556