Chemicals and Drugs

Trifluridine

An antiviral derivative of THYMIDINE used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to HERPES SIMPLEX virus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p557)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An antiviral derivative of THYMIDINE used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to HERPES SIMPLEX virus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p557)

Chemical Identity

Chemical Information

Molecular Formula
C10H11F3N2O5
Molecular Weight
296.20 g/mol
CAS Registry No.
70-00-8
IUPAC Name
1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(trifluoromethyl)pyrimidine-2,4-dione
InChIKey
VSQQQLOSPVPRAZ-RRKCRQDMSA-N
SMILES
C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)O
MeSH Unique ID
D014271
Source
PubChem CID 6256

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

10 entry terms
  • 2'-deoxy-5-(trifluoromethyl)uridine
  • 5-Trifluoromethyl-2'-deoxyuridine
  • Trifluoridine
  • Trifluorothymidine
  • 5 Trifluoromethyl 2' deoxyuridine
  • TFT Ophtiole
  • Triflumann
  • Viromidin
  • Virophta
  • Viroptic

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

1974(1992)

MeSH Record

Previous Indexing

  • Fluorine (1972-1974)
  • Thymidine (1972-1974)

MeSH Hierarchy

Tree Numbers

  1. D03w.383.742.680.705w.900w
  2. D13.570w.230w.855w.900w
  3. D13.570w.685.705w.900w

AMA Style

References

  1. National Library of Medicine. Trifluridine. Medical Subject Headings (MeSH). 2026. Unique ID D014271. http://id.nlm.nih.gov/mesh/2026/D014271
  2. Trifluridine. In: Wikipedia. https://en.wikipedia.org/wiki/Trifluridine
  3. Trifluridine. In: Wikidata. https://www.wikidata.org/wiki/Q2359590
  4. Trifluridine. In: PubChem Compound. CID 6256. https://pubchem.ncbi.nlm.nih.gov/compound/6256