Structured Summary
Abstract
Lysosomal Serine proteases that release N-terminal tripeptide from a polypeptide and cleave peptides between hydrophobic residues. An enzyme that in humans encoded by the TPP1 gene. It is involved in the degradation of bone collagen. Mutations in this gene are associated with the CEROID LIPOFUSCINOSIS, NEURONAL, 2; and SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE CEROID LIPOFUSCINOSIS, NEURONAL, 2; AND SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 7.
MeSH Record
Classification
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MeSH Record
Synonyms
9 entry terms
- CLN2 Protein
- TPP1 Protein
- Tripeptidyl Aminopeptidase I
- Tripeptidyl Peptidase I
- Tripeptidyl Protease I
- Tripeptidyl-Peptidase I
- Peptidase I, Tripeptidyl
- Protein, CLN2
- Protein, TPP1
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2022 (1993)
MeSH Hierarchy
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AMA Style
References
- National Library of Medicine. Tripeptidyl-Peptidase 1. Medical Subject Headings (MeSH). 2026. Unique ID D000091346. http://id.nlm.nih.gov/mesh/2026/D000091346
- Tripeptidyl-Peptidase 1. In: Wikidata. https://www.wikidata.org/wiki/Q21136439