Structured Summary
Abstract
A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
Chemical Identity
Chemical Information
- Molecular Formula
- C24H27NO5S
- Molecular Weight
- 441.5 g/mol
- CAS Registry No.
- 97322-87-7
- IUPAC Name
- 5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
- InChIKey
- GXPHKUHSUJUWKP-UHFFFAOYSA-N
- SMILES
- CC1=C(C2=C(CCC(O2)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C(=C1O)C)C
- MeSH Unique ID
- D000077288
- Source
- PubChem CID 5591
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
6 entry terms
- 5-(4-((6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)benzyl)-2,4-thiazolidinedione) - T
- CS 045
- CS-045
- Prelay
- Rezulin
- CS045
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2019 (1988)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Troglitazone. Medical Subject Headings (MeSH). 2026. Unique ID D000077288. http://id.nlm.nih.gov/mesh/2026/D000077288
- Troglitazone. In: Wikipedia. https://en.wikipedia.org/wiki/Troglitazone
- Troglitazone. In: Wikidata. https://www.wikidata.org/wiki/Q7844989
- Troglitazone. In: PubChem Compound. CID 5591. https://pubchem.ncbi.nlm.nih.gov/compound/5591