Chemicals and Drugs

Tuberous Sclerosis Complex 2 Protein

An intracellular signaling and tumor suppressor protein that forms a complex with TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN (TSC1) and other signaling factors to negatively regulate MTORC1 and affect cell growth and proliferation. It can also function as GTPASE-ACTIVATING PROTEIN (GAP) for RHEB GTPASE to activate mTORC1 independent of its role in the complex. Structurally, it interacts with TSC1 through its N-terminus, which also contains a leucine zipper and coiled-coil region. It also has multiple phosphorylation sites for different cell signaling kinases, a central coiled-coil region, a C-terminal GAP domain and CALMODULIN binding domain. Mutations in the TSC2 gene are associated with TUBEROUS SCLEROSIS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An intracellular signaling and tumor suppressor protein that forms a complex with TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN (TSC1) and other signaling factors to negatively regulate MTORC1 and affect cell growth and proliferation. It can also function as GTPASE-ACTIVATING PROTEIN (GAP) for RHEB GTPASE to activate mTORC1 independent of its role in the complex. Structurally, it interacts with TSC1 through its N-terminus, which also contains a leucine zipper and coiled-coil region. It also has multiple phosphorylation sites for different cell signaling kinases, a central coiled-coil region, a C-terminal GAP domain and CALMODULIN binding domain. Mutations in the TSC2 gene are associated with TUBEROUS SCLEROSIS.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

2 entry terms
  • Tuberin
  • Tuberous Sclerosis 2 Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2019 (1994)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.938w
  2. D12.776w.476.935w
  3. D12.776w.624.776.769w

AMA Style

References

  1. National Library of Medicine. Tuberous Sclerosis Complex 2 Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000077005. http://id.nlm.nih.gov/mesh/2026/D000077005
  2. Tuberous Sclerosis Complex 2 Protein. In: Wikipedia. https://en.wikipedia.org/wiki/TSC2
  3. Tuberous Sclerosis Complex 2 Protein. In: Wikidata. https://www.wikidata.org/wiki/Q21109261