Chemicals and Drugs

Tumor Suppressor p53-Binding Protein 1

A nuclear and cytoplasmic protein that associates with KINETOCHORES and contains a C-terminal TUDOR DOMAIN. It plays a critical role in the cellular response to DNA DAMAGE and localizes to DOUBLE-STRAND DNA BREAKS. It may also function in M PHASE CELL CYCLE CHECKPOINTS and as an enhancer of TUMOR SUPPRESSOR PROTEIN P53-mediated transcriptional activation.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A nuclear and cytoplasmic protein that associates with KINETOCHORES and contains a C-terminal TUDOR DOMAIN. It plays a critical role in the cellular response to DNA DAMAGE and localizes to DOUBLE-STRAND DNA BREAKS. It may also function in M PHASE CELL CYCLE CHECKPOINTS and as an enhancer of TUMOR SUPPRESSOR PROTEIN P53-mediated transcriptional activation.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

6 entry terms
  • 53BP1 Protein
  • TP53BP1 Protein
  • Tumor Protein p53-Binding Protein, 1
  • p202 Protein
  • Tumor Protein p53 Binding Protein, 1
  • Tumor Suppressor p53 Binding Protein 1

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • Chromosomal Proteins, Non-Histone (2005-2016)
  • DNA-Binding Proteins (2005-2016)
  • Intracellular Signaling Peptides and Proteins (2005-2016)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.260w.805
  2. D12.776w.660w.235.850
  3. D12.776w.664w.235.950

AMA Style

References

  1. National Library of Medicine. Tumor Suppressor p53-Binding Protein 1. Medical Subject Headings (MeSH). 2026. Unique ID D000071857. http://id.nlm.nih.gov/mesh/2026/D000071857
  2. Tumor Suppressor p53-Binding Protein 1. In: Wikidata. https://www.wikidata.org/wiki/Q21148788