Chemicals and Drugs

Type 3 Cyclic Nucleotide Phosphodiesterases

A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of CYCLIC GMP to an allosteric domain found on the enzyme and through phosphorylation by regulatory kinases such as PROTEIN KINASE A and PROTEIN KINASE B. The two members of this family are referred to as type 3A, and type 3B, and are each product of a distinct gene. In addition multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of CYCLIC GMP to an allosteric domain found on the enzyme and through phosphorylation by regulatory kinases such as PROTEIN KINASE A and PROTEIN KINASE B. The two members of this family are referred to as type 3A, and type 3B, and are each product of a distinct gene. In addition multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing.

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Classification

Broader headings

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MeSH Record

Synonyms

12 entry terms
  • Cyclic Nucleotide Phosphodiesterase PDE3 Family
  • Cyclic Nucleotide Phosphodiesterases, Type 3
  • Phosphodiesterase III
  • cGMP-Inhibited Cyclic Nucleotide Phosphodiesterase
  • cGMP-Inhibited Phosphodiesterase
  • Phosphodiesterase, cGMP-Inhibited
  • cGMP Inhibited Cyclic Nucleotide Phosphodiesterase
  • cGMP Inhibited Phosphodiesterase
  • Cyclic Nucleotide Phosphodiesterases, Type 3A
  • Cyclic Nucleotide Phosphodiesterases, Type 3B
  • Phosphodiesterase 3A
  • Phosphodiesterase 3B

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2008(1995)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.352w.640.150w.300w
  2. D12.776w.476.008w.300w

AMA Style

References

  1. National Library of Medicine. Type 3 Cyclic Nucleotide Phosphodiesterases. Medical Subject Headings (MeSH). 2026. Unique ID D054684. http://id.nlm.nih.gov/mesh/2026/D054684
  2. Type 3 Cyclic Nucleotide Phosphodiesterases. In: Wikipedia. https://en.wikipedia.org/wiki/Phosphodiesterase_3
  3. Type 3 Cyclic Nucleotide Phosphodiesterases. In: Wikidata. https://www.wikidata.org/wiki/Q906688