Chemicals and Drugs

Type II Secretion Systems

Gram-negative bacterial secretion systems which carry out the secretion of folded proteins.T2SSs secrete folded proteins from the PERIPLASMIC SPACE that have been exported there by SEC TRANSLOCASE or TAT SECRETION SYSTEMS, or they secrete folded proteins directly from the CYTOPLASM. The T2SSs have four substructures, an ATPase, an inner membrane platform, a pseudopilin, and secretin, an outer membrane complex which is a channel for secretion. (This bacterial secretin is not the same as the mammalian hormone also named SECRETIN.)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Gram-negative bacterial secretion systems which carry out the secretion of folded proteins.T2SSs secrete folded proteins from the PERIPLASMIC SPACE that have been exported there by SEC TRANSLOCASE or TAT SECRETION SYSTEMS, or they secrete folded proteins directly from the CYTOPLASM. The T2SSs have four substructures, an ATPase, an inner membrane platform, a pseudopilin, and secretin, an outer membrane complex which is a channel for secretion. (This bacterial secretin is not the same as the mammalian hormone also named SECRETIN.)

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

7 entry terms
  • Bacterial Secretion System, Type II
  • T2SS Secretion System
  • Type 2 Secretion System
  • Type 2 Secretion Systems
  • Type II Secretion System
  • Secretion System, T2SS
  • System, T2SS Secretion

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2016

MeSH Record

Previous Indexing

  • Bacterial Secretion Systems (2010-2015)

MeSH Hierarchy

Tree Number

  1. D05.500w.890.500w.750w

AMA Style

References

  1. National Library of Medicine. Type II Secretion Systems. Medical Subject Headings (MeSH). 2026. Unique ID D000069178. http://id.nlm.nih.gov/mesh/2026/D000069178
  2. Type II Secretion Systems. In: Wikipedia. https://en.wikipedia.org/wiki/Type_II_secretion_system
  3. Type II Secretion Systems. In: Wikidata. https://www.wikidata.org/wiki/Q21758669