Chemicals and Drugs

Type I Secretion Systems

Gram-negative bacterial secretion systems which translocate effectors in a single step across the inner and outer membranes. The one-step secretion is carried out by a channel that passes from the CYTOPLASM, through the inner membrane, PERIPLASMIC SPACE, and outer membrane, to the EXTRACELLULAR SPACE. The specificity of type I secretions systems are determined by the specificity of the three subcomponents forming the channel - an ATP transporter (ATP-BINDING CASSETTE TRANSPORTERS); a membrane fusion protein (MEMBRANE FUSION PROTEINS); and an outer membrane protein (BACTERIAL OUTER MEMBRANE PROTEINS.)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Gram-negative bacterial secretion systems which translocate effectors in a single step across the inner and outer membranes. The one-step secretion is carried out by a channel that passes from the CYTOPLASM, through the inner membrane, PERIPLASMIC SPACE, and outer membrane, to the EXTRACELLULAR SPACE. The specificity of type I secretions systems are determined by the specificity of the three subcomponents forming the channel - an ATP transporter (ATP-BINDING CASSETTE TRANSPORTERS); a membrane fusion protein (MEMBRANE FUSION PROTEINS); and an outer membrane protein (BACTERIAL OUTER MEMBRANE PROTEINS.)

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

7 entry terms
  • Bacterial Secretion Systems, Type I
  • T1SS Secretion System
  • Type 1 Secretion System
  • Type 1 Secretion Systems
  • Type I Secretion System
  • Secretion System, T1SS
  • System, T1SS Secretion

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2016

MeSH Record

Previous Indexing

  • Bacterial Secretion Systems (2010-2015)

MeSH Hierarchy

Tree Number

  1. D05.500w.890.500w.500

AMA Style

References

  1. National Library of Medicine. Type I Secretion Systems. Medical Subject Headings (MeSH). 2026. Unique ID D000069177. http://id.nlm.nih.gov/mesh/2026/D000069177
  2. Type I Secretion Systems. In: Wikidata. https://www.wikidata.org/wiki/Q77446005