Chemicals and Drugs

U1 Small Nuclear Ribonucleoprotein

A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U1 snRNP along with other small nuclear ribonucleoproteins (U2, U4-U6, and U5) assemble into SPLICEOSOMES that remove introns from pre-mRNA by splicing. The U1 snRNA forms base pairs with conserved sequence motifs at the 5'-splice site and recognizes both the 5'- and 3'-splice sites and may have a fundamental role in aligning the two sites for the splicing reaction.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U1 snRNP along with other small nuclear ribonucleoproteins (U2, U4-U6, and U5) assemble into SPLICEOSOMES that remove introns from pre-mRNA by splicing. The U1 snRNA forms base pairs with conserved sequence motifs at the 5'-splice site and recognizes both the 5'- and 3'-splice sites and may have a fundamental role in aligning the two sites for the splicing reaction.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

5 entry terms
  • Ribonucleoprotein, U1 Small Nuclear
  • Ribonucleoproteins, Small, U1
  • Small Nuclear Ribonucleoproteins, U1
  • U1 Small Nuclear Ribonucleoproteins
  • U1 snRNP

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2000; U1 SNRNP was U1-RNP (SY) to SMALL RIBONUCLEOPROTEINS (NM) 1982-92

MeSH Record

Previous Indexing

  • Ribonucleoproteins (1975-1992)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.725w.500w.875w.600
  2. D12.776w.157w.725w.829w.313
  3. D12.776w.664w.962w.500w.875w.600
  4. D12.776w.664w.962w.829w.313

AMA Style

References

  1. National Library of Medicine. U1 Small Nuclear Ribonucleoprotein. Medical Subject Headings (MeSH). 2026. Unique ID D017412. http://id.nlm.nih.gov/mesh/2026/D017412
  2. U1 Small Nuclear Ribonucleoprotein. In: Wikidata. https://www.wikidata.org/wiki/Q21100759