Chemicals and Drugs

Uncoupling Agents

Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes.

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Synonyms

1 entry terms
  • Agents, Uncoupling

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Aspects Covered

22 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

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Indexing Annotation

enzyme inhib

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History Note

72(69)

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Previous Indexing

  • Oxidative Phosphorylation/drug effects (1966-1968)
  • Oxidoreductases/antagonists & inhibitors (1968)

MeSH Hierarchy

Tree Number

  1. D27.505.519w.389w.936

AMA Style

References

  1. National Library of Medicine. Uncoupling Agents. Medical Subject Headings (MeSH). 2026. Unique ID D014475. http://id.nlm.nih.gov/mesh/2026/D014475
  2. Uncoupling Agents. In: Wikidata. https://www.wikidata.org/wiki/Q50430187