Structured Summary
Abstract
An indole sulfonamide compound and inhibitor of BRAF KINASES that is used for the treatment of unresectable or metastatic MELANOMA.
Chemical Identity
Chemical Information
- Molecular Formula
- C23H18ClF2N3O3S
- Molecular Weight
- 489.9 g/mol
- CAS Registry No.
- 918504-65-1
- IUPAC Name
- N-[3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]propane-1-sulfonamide
- InChIKey
- GPXBXXGIAQBQNI-UHFFFAOYSA-N
- SMILES
- CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)Cl)F
- MeSH Unique ID
- D000077484
- Source
- PubChem CID 42611257
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
7 entry terms
- PLX 4032
- PLX4032
- R05185426
- RG-7204
- RG7204
- Zelboraf
- RG 7204
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2019 (2010)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Vemurafenib. Medical Subject Headings (MeSH). 2026. Unique ID D000077484. http://id.nlm.nih.gov/mesh/2026/D000077484
- Vemurafenib. In: Wikipedia. https://en.wikipedia.org/wiki/Vemurafenib
- Vemurafenib. In: Wikidata. https://www.wikidata.org/wiki/Q423111
- Vemurafenib. In: PubChem Compound. CID 42611257. https://pubchem.ncbi.nlm.nih.gov/compound/42611257