Chemicals and Drugs

Vitamin D-Binding Protein

An alpha-globulin found in the plasma of man and other vertebrates. It is apparently synthesized in the liver and carries vitamin D and its metabolites through the circulation and mediates the response of tissue. It is also known as group-specific component (Gc). Gc subtypes are used to determine specific phenotypes and gene frequencies. These data are employed in the classification of population groups, paternity investigations, and in forensic medicine.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An alpha-globulin found in the plasma of man and other vertebrates. It is apparently synthesized in the liver and carries vitamin D and its metabolites through the circulation and mediates the response of tissue. It is also known as group-specific component (Gc). Gc subtypes are used to determine specific phenotypes and gene frequencies. These data are employed in the classification of population groups, paternity investigations, and in forensic medicine.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

19 entry terms
  • 25-HCC-Binding Protein
  • 25-Hydroxycholecalciferol-Binding Protein
  • 25-Hydroxyvitamin D-Binding Protein
  • Calciferol-Binding Protein
  • Gc Globulin
  • Group-Specific Component Globulin
  • Transcalciferin
  • Vitamin D-Binding Globulin
  • 25 HCC Binding Protein
  • 25 Hydroxycholecalciferol Binding Protein
  • 25 Hydroxyvitamin D Binding Protein
  • Calciferol Binding Protein
  • Component Globulin, Group-Specific
  • Globulin, Gc
  • Globulin, Group-Specific Component
  • Globulin, Vitamin D-Binding
  • Group Specific Component Globulin
  • Vitamin D Binding Globulin
  • Vitamin D Binding Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

85

MeSH Record

Previous Indexing

  • Alpha Globulins (1966-1984)
  • Carrier Proteins (1971-1984)
  • Proteins (1966-1971)
  • Vitamin D (1966-1984)

MeSH Hierarchy

Tree Number

  1. D12.776w.157w.920

AMA Style

References

  1. National Library of Medicine. Vitamin D-Binding Protein. Medical Subject Headings (MeSH). 2026. Unique ID D014809. http://id.nlm.nih.gov/mesh/2026/D014809
  2. Vitamin D-Binding Protein. In: Wikidata. https://www.wikidata.org/wiki/Q24739181