Chemicals and Drugs

Vitamin K 1

A family of phylloquinones that contains a ring of 2-methyl-1,4-naphthoquinone and an isoprenoid side chain. Members of this group of vitamin K 1 have only one double bond on the proximal isoprene unit. Rich sources of vitamin K 1 include green plants, algae, and photosynthetic bacteria. Vitamin K1 has antihemorrhagic and prothrombogenic activity.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A family of phylloquinones that contains a ring of 2-methyl-1,4-naphthoquinone and an isoprenoid side chain. Members of this group of vitamin K 1 have only one double bond on the proximal isoprene unit. Rich sources of vitamin K 1 include green plants, algae, and photosynthetic bacteria. Vitamin K1 has antihemorrhagic and prothrombogenic activity.

Chemical Identity

Chemical Information

Molecular Formula
C31H46O2
Molecular Weight
450.7 g/mol
CAS Registry No.
84-80-0
IUPAC Name
2-methyl-3-[(E,7R,11R)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione
InChIKey
MBWXNTAXLNYFJB-NKFFZRIASA-N
SMILES
CC1=C(C(=O)C2=CC=CC=C2C1=O)C/C=C(\C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C
MeSH Unique ID
D010837
Source
PubChem CID 5284607

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

7 entry terms
  • Phylloquinone
  • Phytomenadione
  • Phytonadione
  • Vitamin K1
  • Aquamephyton
  • Konakion
  • Phyllohydroquinone

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

deficiency: coordinate VITAMIN K 1 (IM) with VITAMIN K DEFICIENCY (IM)

MeSH Record

History Note

use PHYTONADIONE 1964-2001

MeSH Record

Previous Indexing

  • Phytonadione (1964-2001)

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.426w.559w.847w.638.721w.374w.689w
  2. D02w.455w.849w.291w.523w.500w.689w
  3. D02w.806w.550w.625w
  4. D04w.615w.638.721w.374w.689w

AMA Style

References

  1. National Library of Medicine. Vitamin K 1. Medical Subject Headings (MeSH). 2026. Unique ID D010837. http://id.nlm.nih.gov/mesh/2026/D010837
  2. Vitamin K 1. In: Wikipedia. https://en.wikipedia.org/wiki/Phytomenadione
  3. Vitamin K 1. In: Wikidata. https://www.wikidata.org/wiki/Q186093
  4. Vitamin K 1. In: PubChem Compound. CID 5284607. https://pubchem.ncbi.nlm.nih.gov/compound/5284607