Phenomena and Processes

WW Domains

An approximately 40 amino acid protein domain that occurs in a variety of unrelated proteins and may be repeated up to four times in some proteins. It is characterized by two TRYPTOPHAN residues (WW) about 20 amino acids apart and folds into a stable triple-stranded BETA-SHEET. It binds PROLINE-RICH PROTEIN DOMAINS and PHOSPHOSERINE or PHOSPHOTHREONINE-containing protein domains that occur in many signal-transducing and cytoskeletal proteins such as DYSTROPHIN.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An approximately 40 amino acid protein domain that occurs in a variety of unrelated proteins and may be repeated up to four times in some proteins. It is characterized by two TRYPTOPHAN residues (WW) about 20 amino acids apart and folds into a stable triple-stranded BETA-SHEET. It binds PROLINE-RICH PROTEIN DOMAINS and PHOSPHOSERINE or PHOSPHOTHREONINE-containing protein domains that occur in many signal-transducing and cytoskeletal proteins such as DYSTROPHIN.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

3 entry terms
  • WW Domain
  • Domain, WW
  • Domains, WW

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Amino Acid Sequence (1996-2017)
  • Protein Structure, Tertiary (1999-2017)

MeSH Hierarchy

Tree Number

  1. G02.111.570.820w.709.275.750w.500.937w

AMA Style

References

  1. National Library of Medicine. WW Domains. Medical Subject Headings (MeSH). 2026. Unique ID D000074585. http://id.nlm.nih.gov/mesh/2026/D000074585
  2. WW Domains. In: Wikipedia. https://en.wikipedia.org/wiki/WW_domain
  3. WW Domains. In: Wikidata. https://www.wikidata.org/wiki/Q24726881