Structured Summary
Abstract
A DNA-dependent helicase and 3'-5' exonuclease. It has 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang and binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and HOLLIDAY JUNCTIONS. Mutations in the WRN gene are associated with WERNER SYNDROME.
MeSH Record
Classification
Related Concepts
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MeSH Record
Synonyms
7 entry terms
- RECQ3 Protein
- RECQL2 Protein
- Werner Syndrome ATP-Dependent Helicase
- Werner Syndrome RecQ-Like Helicase
- Helicase, Werner Syndrome
- Werner Syndrome ATP Dependent Helicase
- Werner Syndrome RecQ Like Helicase
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2017
MeSH Record
Previous Indexing
- Exodeoxyribonucleases (1996-2016)
- RecQ Helicases (2006-2016)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Werner Syndrome Helicase. Medical Subject Headings (MeSH). 2026. Unique ID D000071657. http://id.nlm.nih.gov/mesh/2026/D000071657
- Werner Syndrome Helicase. In: Wikidata. https://www.wikidata.org/wiki/Q6591532