Diseases

Wolman Disease

The severe infantile form of inherited lysosomal lipid storage diseases due to deficiency of acid lipase (STEROL ESTERASE). It is characterized by the accumulation of neutral lipids, particularly CHOLESTEROL ESTERS in leukocytes, fibroblasts, and hepatocytes. It is also known as Wolman's xanthomatosis and is an allelic variant of CHOLESTEROL ESTER STORAGE DISEASE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The severe infantile form of inherited lysosomal lipid storage diseases due to deficiency of acid lipase (STEROL ESTERASE). It is characterized by the accumulation of neutral lipids, particularly CHOLESTEROL ESTERS in leukocytes, fibroblasts, and hepatocytes. It is also known as Wolman's xanthomatosis and is an allelic variant of CHOLESTEROL ESTER STORAGE DISEASE.

MeSH Record

Classification

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

38 entry terms
  • Acid Cholesteryl Ester Hydrolase Deficiency, Wolman Type
  • Acid Lipase Deficiency
  • Cholesterol ester hydrolase deficiency
  • Familial Xanthomatosis
  • LAL Deficiency
  • LIPA Deficiency
  • Liposomal Acid Lipase Deficiency, Wolman Type
  • Lysosomal Acid Lipase Deficiency
  • Wolman Disease with Hypolipoproteinemia and Acanthocytosis
  • Wolman's Disease
  • Xanthomatosis, Familial
  • Xanthomatosis, Wolman's
  • Acid Lipase Deficiencies
  • Deficiencies, Acid Lipase
  • Deficiencies, LAL
  • Deficiencies, LIPA
  • Deficiency, Acid Lipase
  • Deficiency, LAL
  • Deficiency, LIPA
  • Disease, Wolman
  • Disease, Wolman's
  • Familial Xanthomatoses
  • LAL Deficiencies
  • LIPA Deficiencies
  • Lipase Deficiencies, Acid
  • Lipase Deficiency, Acid
  • Wolman's Xanthomatosis
  • Wolmans Disease
  • Xanthomatoses, Familial
  • Xanthomatosis, Wolman
  • Xanthomatosis, Wolmans
  • Acid Cholesteryl Ester Hydrolase Deficiency, Type 2
  • Acid Lipase Disease
  • Acid Lipase Diseases
  • Disease, Acid Lipase
  • Diseases, Acid Lipase
  • Lipase Disease, Acid
  • Lipase Diseases, Acid

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

1989

MeSH Record

Previous Indexing

  • Cholesterol Esters (1978-1988)
  • Lipase (1966-1988)
  • Lipid Metabolism, Inborn Errors (1966-1988)
  • Lipoidosis (1966-1988)
  • Xanthomatosis (1966-1988)

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. Wolman Disease. Medical Subject Headings (MeSH). 2026. Unique ID D015223. http://id.nlm.nih.gov/mesh/2026/D015223
  2. Wolman Disease. In: Wikipedia. https://en.wikipedia.org/wiki/Lysosomal_acid_lipase_deficiency
  3. Wolman Disease. In: Wikidata. https://www.wikidata.org/wiki/Q6710283