Chemicals and Drugs

Zinc Finger E-box-Binding Homeobox 1

A transcription factor characterized by N-terminal and C-terminal CYS2-HIS2 ZINC FINGERS separated by a homeobox. It represses the expression of E-CADHERIN to induce the EPITHELIAL-MESENCHYMAL TRANSITION. It also represses PROTO-ONCOGENE PROTEINS C-BCL-6; regulates the cell type-specific expression of SODIUM-POTASSIUM-EXCHANGING ATPASE; and promotes neuronal differentiation.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A transcription factor characterized by N-terminal and C-terminal CYS2-HIS2 ZINC FINGERS separated by a homeobox. It represses the expression of E-CADHERIN to induce the EPITHELIAL-MESENCHYMAL TRANSITION. It also represses PROTO-ONCOGENE PROTEINS C-BCL-6; regulates the cell type-specific expression of SODIUM-POTASSIUM-EXCHANGING ATPASE; and promotes neuronal differentiation.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

7 entry terms
  • NIL-2-A Zinc Finger Protein
  • TCF8 Protein
  • Transcription Factor 8
  • Zeb1 Transcription Factor
  • NIL 2 A Zinc Finger Protein
  • Transcription Factor, Zeb1
  • Zinc Finger E box Binding Homeobox 1

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • Homeodomain Proteins (2004-2016)
  • Transcription Factors (2004-2016)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.260w.400.906
  2. D12.776w.260w.703.800
  3. D12.776w.930w.780.945

AMA Style

References

  1. National Library of Medicine. Zinc Finger E-box-Binding Homeobox 1. Medical Subject Headings (MeSH). 2026. Unique ID D000071799. http://id.nlm.nih.gov/mesh/2026/D000071799
  2. Zinc Finger E-box-Binding Homeobox 1. In: Wikidata. https://www.wikidata.org/wiki/Q21124742