Structured Summary
Abstract
A transcription factor that consists of 8 CYS2-HIS2 ZINC FINGERS flanking a central HOMEOBOX. It binds to the 5'-CACCT-3' DNA sequence located within E-BOX ELEMENTS of many genes essential for embryonic growth and development and regulates their activity; it represses transcription of the E-CADHERIN gene. Mutations in the ZEB2 gene are associated with MOWAT-WILSON SYNDROME.
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Classification
Broader headings
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MeSH Record
Synonyms
7 entry terms
- Smad-Interacting Protein 1
- Zeb2 Transcription Factor
- Zinc Finger E-box Binding Homeobox 2 Protein
- Smad Interacting Protein 1
- Transcription Factor, Zeb2
- Zinc Finger E box Binding Homeobox 2
- Zinc Finger E box Binding Homeobox 2 Protein
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2018
MeSH Record
Previous Indexing
- Homeodomain Proteins (2004-2017)
- Repressor Proteins (2004-2017)
MeSH Hierarchy
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AMA Style
References
- National Library of Medicine. Zinc Finger E-box Binding Homeobox 2. Medical Subject Headings (MeSH). 2026. Unique ID D000074165. http://id.nlm.nih.gov/mesh/2026/D000074165
- Zinc Finger E-box Binding Homeobox 2. In: Wikidata. https://www.wikidata.org/wiki/Q8063006